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The Dog's Most Wanted star, who lost his wife and business partner, Beth Chapman, to cancer in June, shared the engagement news with The Sun , saying he proposed while they have been socially isolating together at his home in Colorado.

He said he got down on one knee. He called her over, "So I put all the food in the kitchen and I came in and he said, 'I know that God brought you into my life and I don't want to spend one moment of it without you.

And he got down on one knee and he opened the ring box and he said, 'Will you marry me and spend the rest of our lives together? She added, "Who can say no to that?

It was wonderful. They also enjoy hiking together, with pets, and fishing. Chapman shared they bonded over both recently losing spouses to cancer.

He lost the love of his life, Beth, last June after her long battle with cancer. She was a jazz musician playing the bass , a carpenter, a dog trainer, a waitress, and a Playboy Bunny.

Polly Matzinger was a section head at the U. Matzinger and her coworkers referred to the lab as the "Ghost Lab" when listing their affiliation in papers.

The nickname was given to the lab by her colleagues when Matzinger first arrived at the NIH because she spent the first nine months studying a new field chaos theory that she thought might apply to the immune system, and the lab sat empty.

The T-Cell Tolerance and Memory Section was incorporated into the Laboratory of Immunogenetics , but without any funding for research, and Matzinger's research was effectively shut down.

Since that time she has given a series of eight lectures explaining the function of the immune system from the point of view of the danger model.

These lectures were taped and can be found on the NIH videocast website. In , drawing on the ideas of Thomas Kuhn , Charles Janeway proposed that the old immunological paradigm had reached the limits of its usefulness—or, as he described it, the asymptote of the increase in knowledge which it had brought.

Janeway argued that the innate immune system was the real gatekeeper of whether the immune system responded or did not respond.

He also argued that the innate immune system used ancient pattern-recognition receptors to make these decisions, recognizing a pathogen by its unchanging characteristics.

In a article entitled "Tolerance, Danger and the Extended Family", Matzinger went several steps further by laying out the idea that antigen-presenting cells respond to "danger signals" — most notably from cells undergoing injury, stress or "bad cell death" as opposed to apoptosis , controlled cell death.

The alarm signals released by these cells let the immune system know that there is a problem requiring an immune response.

She argued that T cells and the immune response they orchestrate occurs not because of a neonatal definition of "self", as in the previous model, nor because of ancient definitions of pathogens, as in Janeway's argument, but because of a dynamic and constantly updated response to danger as defined by cellular damage.

She has now extended the model to hypothesize that tissues not only send signals alerting the immune system to local damage and stress, but that the tissues also determine the immune response appropriate for that tissue.

Before her lab was closed, it was working on experiments to test that hypothesis. She is currently seeking collaborations to continue the research.

The danger model has not won universal acceptance. Some immunologists, following Janeway's ideas more directly, believe that the immune response is mainly fueled by innate evolutionarily conserved "pattern recognition receptors" which recognize patterns expressed by microbes such as bacteria, and do not see cell death in the absence of pathogens as a primary driver of immune responses.

These ideas however, do not explain how the immune system rejects tumors, induce autoimmune diseases , or generate allergy and asthma.

Seong and Matzinger have suggested that the "patterns" that the immune system recognizes on bacteria are not as different from the alarm signals released by damaged cells as one might have thought [ citation needed ].

They suggested that, because life evolved in water, the hydrophobic portions of molecules are normally hidden in the internal parts of molecules or other structures like membranes and that the sudden exposure of a hydrophobic portion is a sure sign that some injury or damage has occurred.

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Chapman and Frane declared their love for one another publicly on social media late last month, giving hints that things between them had quickly gotten serious.

Chapman proposed to Angell on an episode of Dr. Oz in January, but they were not technically engaged apparently and they split soon after.

Read more from Yahoo Entertainment:. Entertainment Home. Follow Us. Suzy Byrne Editor, Yahoo Entertainment.

Yahoo Celebrity May 4, They bonded over the deaths of their respective spouses, they say. In a article in Nature Immunology , Matzinger makes a case for what she now views as the most important implication of the danger model: that the tissues of the body are a large part of what drive immune response.

She argues that immunologists have had overly simplistic and schematic ideas about immune response because of the limits of their assays, and that organs are likely to induce immune responses that are best-suited to defending the organ from the damage of microbes but also from the damage of the immune system itself.

She also asserts that the relationship of the immune system to commensal bacteria remains poorly understood but is likely to be important. Matzinger argues that the idea of DAMPs may explain why Toll-like receptors seem to respond both to external and endogenous signals while acknowledging controversy over this issue.

By emphasizing her theory that the tissues drive the nature of the immune response i. There is now a growing body of work on regulatory T cells which argues that immune activity is stopped by a special subset of T cells.

These ideas challenge several of the key specifics of Matzinger's model. Matzinger argues that these cells are misinterpreted because their functions have not been explored enough.

To date with rare exceptions these cells have been tested almost exclusively for their ability to suppress highly inflammatory immune response types.

The exceptions are illustrative in that they show that regulatory T cells can also act as helper T cells for immune responses in the gut and mucosal tissue.

Matzinger argues that their function is to maintain the right kinds of immune responses in the right places, and that they are controlled by signals from the tissues that they protect.

Other immunologists have often adapted parts of Matzinger's ideas without adopting the danger model as a theoretical framework. Indeed, in an era of increasingly detailed molecular work, many immunologists simply avoid constructing an alternative broad theory of immune function.

One immunologist believes that the immune system is not a single system at all, and is instead a set of mechanisms "cobbled together" by evolution.

For both of these reasons, Matzinger has had to defend her larger theory, but also has had to defend the value of grand theory itself.

She argues that, without a theoretical framework on which to hang the data, much will be missed. In one of her first publications, a paper for the Journal of Experimental Medicine , she listed a dog as a coauthor.

From Wikipedia, the free encyclopedia. American immunologist. Infobase Publishing. Archived from the original on 11 May Sungguh tepat predikat terdepan dalam berinovasi di bidang teknologi layanan perbankan di Indonesia disematkan pada BII Maybank.

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